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Figure 1. Synaptic-like Vesicles Accumulate in Pioneer DRG Growth Cones at the DREZ (A) Confocal z projections of DRG pioneer axon navigation in a Tg(sox10:syn-gfp); Tg(sox10:mcherry) animal from a 24-h time-lapse starting at 48 hpf. Syn-GFP vesicles accumulate in the growth cone upon DREZ contact. White arrows denote Syn-GFP concentrate. Dashed orange boxes denote DREZ. (B) Tracing of growth cone Syn-GFP intensity throughout navigation. Blue box denotes DREZ entry. Dashed line denotes SEM (n = 4 DRG). (C) Growth cone Syn-GFP intensities before, during, and after DREZ localization (n = 4 DRG). (D) Quantification of actin clusters in DREZ-located DRG pioneer axons containing vesicle puncta (n = 16 growth cones; n = 52 actin clusters). (E) Super-resolution DeSOS image of DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synapsin and <t>Rab8.</t> Dashed white box denotes single-plane insets on right. Arrowheads denote Lifeact-GFP, Synapsin, and Rab8 puncta in the pioneer growth cone. (F and G) Super-resolution DeSOS images of a DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synaptotagmin (F) and SV2 (G). Dashed white box denotes single-plane insets on right. Arrowheads denote colocalized Lifeact-GFP and vesicle puncta. Tukey’s HSD used for (C). SEM is shown. Scale bars, 10 mm. See also Figure S1 and Video S1.
Rab8, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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3g1  (Novus Biologicals)
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Figure 1. Synaptic-like Vesicles Accumulate in Pioneer DRG Growth Cones at the DREZ (A) Confocal z projections of DRG pioneer axon navigation in a Tg(sox10:syn-gfp); Tg(sox10:mcherry) animal from a 24-h time-lapse starting at 48 hpf. Syn-GFP vesicles accumulate in the growth cone upon DREZ contact. White arrows denote Syn-GFP concentrate. Dashed orange boxes denote DREZ. (B) Tracing of growth cone Syn-GFP intensity throughout navigation. Blue box denotes DREZ entry. Dashed line denotes SEM (n = 4 DRG). (C) Growth cone Syn-GFP intensities before, during, and after DREZ localization (n = 4 DRG). (D) Quantification of actin clusters in DREZ-located DRG pioneer axons containing vesicle puncta (n = 16 growth cones; n = 52 actin clusters). (E) Super-resolution DeSOS image of DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synapsin and <t>Rab8.</t> Dashed white box denotes single-plane insets on right. Arrowheads denote Lifeact-GFP, Synapsin, and Rab8 puncta in the pioneer growth cone. (F and G) Super-resolution DeSOS images of a DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synaptotagmin (F) and SV2 (G). Dashed white box denotes single-plane insets on right. Arrowheads denote colocalized Lifeact-GFP and vesicle puncta. Tukey’s HSD used for (C). SEM is shown. Scale bars, 10 mm. See also Figure S1 and Video S1.
3g1, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/3g1/product/Novus Biologicals
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mouse monoclonal anti rab8a  (Novus Biologicals)
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Figure 1. Synaptic-like Vesicles Accumulate in Pioneer DRG Growth Cones at the DREZ (A) Confocal z projections of DRG pioneer axon navigation in a Tg(sox10:syn-gfp); Tg(sox10:mcherry) animal from a 24-h time-lapse starting at 48 hpf. Syn-GFP vesicles accumulate in the growth cone upon DREZ contact. White arrows denote Syn-GFP concentrate. Dashed orange boxes denote DREZ. (B) Tracing of growth cone Syn-GFP intensity throughout navigation. Blue box denotes DREZ entry. Dashed line denotes SEM (n = 4 DRG). (C) Growth cone Syn-GFP intensities before, during, and after DREZ localization (n = 4 DRG). (D) Quantification of actin clusters in DREZ-located DRG pioneer axons containing vesicle puncta (n = 16 growth cones; n = 52 actin clusters). (E) Super-resolution DeSOS image of DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synapsin and <t>Rab8.</t> Dashed white box denotes single-plane insets on right. Arrowheads denote Lifeact-GFP, Synapsin, and Rab8 puncta in the pioneer growth cone. (F and G) Super-resolution DeSOS images of a DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synaptotagmin (F) and SV2 (G). Dashed white box denotes single-plane insets on right. Arrowheads denote colocalized Lifeact-GFP and vesicle puncta. Tukey’s HSD used for (C). SEM is shown. Scale bars, 10 mm. See also Figure S1 and Video S1.
Mouse Monoclonal Anti Rab8a, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse monoclonal anti rab8a/product/Novus Biologicals
Average 90 stars, based on 1 article reviews
mouse monoclonal anti rab8a - by Bioz Stars, 2026-03
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Figure 1. Synaptic-like Vesicles Accumulate in Pioneer DRG Growth Cones at the DREZ (A) Confocal z projections of DRG pioneer axon navigation in a Tg(sox10:syn-gfp); Tg(sox10:mcherry) animal from a 24-h time-lapse starting at 48 hpf. Syn-GFP vesicles accumulate in the growth cone upon DREZ contact. White arrows denote Syn-GFP concentrate. Dashed orange boxes denote DREZ. (B) Tracing of growth cone Syn-GFP intensity throughout navigation. Blue box denotes DREZ entry. Dashed line denotes SEM (n = 4 DRG). (C) Growth cone Syn-GFP intensities before, during, and after DREZ localization (n = 4 DRG). (D) Quantification of actin clusters in DREZ-located DRG pioneer axons containing vesicle puncta (n = 16 growth cones; n = 52 actin clusters). (E) Super-resolution DeSOS image of DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synapsin and <t>Rab8.</t> Dashed white box denotes single-plane insets on right. Arrowheads denote Lifeact-GFP, Synapsin, and Rab8 puncta in the pioneer growth cone. (F and G) Super-resolution DeSOS images of a DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synaptotagmin (F) and SV2 (G). Dashed white box denotes single-plane insets on right. Arrowheads denote colocalized Lifeact-GFP and vesicle puncta. Tukey’s HSD used for (C). SEM is shown. Scale bars, 10 mm. See also Figure S1 and Video S1.
Rab8a Antibody Clone 3g1, supplied by Abnova, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
rab8a antibody clone 3g1 - by Bioz Stars, 2026-03
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mouse anti rab8a  (Novus Biologicals)
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Novus Biologicals mouse anti rab8a
Figure 1. Synaptic-like Vesicles Accumulate in Pioneer DRG Growth Cones at the DREZ (A) Confocal z projections of DRG pioneer axon navigation in a Tg(sox10:syn-gfp); Tg(sox10:mcherry) animal from a 24-h time-lapse starting at 48 hpf. Syn-GFP vesicles accumulate in the growth cone upon DREZ contact. White arrows denote Syn-GFP concentrate. Dashed orange boxes denote DREZ. (B) Tracing of growth cone Syn-GFP intensity throughout navigation. Blue box denotes DREZ entry. Dashed line denotes SEM (n = 4 DRG). (C) Growth cone Syn-GFP intensities before, during, and after DREZ localization (n = 4 DRG). (D) Quantification of actin clusters in DREZ-located DRG pioneer axons containing vesicle puncta (n = 16 growth cones; n = 52 actin clusters). (E) Super-resolution DeSOS image of DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synapsin and <t>Rab8.</t> Dashed white box denotes single-plane insets on right. Arrowheads denote Lifeact-GFP, Synapsin, and Rab8 puncta in the pioneer growth cone. (F and G) Super-resolution DeSOS images of a DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synaptotagmin (F) and SV2 (G). Dashed white box denotes single-plane insets on right. Arrowheads denote colocalized Lifeact-GFP and vesicle puncta. Tukey’s HSD used for (C). SEM is shown. Scale bars, 10 mm. See also Figure S1 and Video S1.
Mouse Anti Rab8a, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse anti rab8a/product/Novus Biologicals
Average 90 stars, based on 1 article reviews
mouse anti rab8a - by Bioz Stars, 2026-03
90/100 stars
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Image Search Results


Figure 1. Synaptic-like Vesicles Accumulate in Pioneer DRG Growth Cones at the DREZ (A) Confocal z projections of DRG pioneer axon navigation in a Tg(sox10:syn-gfp); Tg(sox10:mcherry) animal from a 24-h time-lapse starting at 48 hpf. Syn-GFP vesicles accumulate in the growth cone upon DREZ contact. White arrows denote Syn-GFP concentrate. Dashed orange boxes denote DREZ. (B) Tracing of growth cone Syn-GFP intensity throughout navigation. Blue box denotes DREZ entry. Dashed line denotes SEM (n = 4 DRG). (C) Growth cone Syn-GFP intensities before, during, and after DREZ localization (n = 4 DRG). (D) Quantification of actin clusters in DREZ-located DRG pioneer axons containing vesicle puncta (n = 16 growth cones; n = 52 actin clusters). (E) Super-resolution DeSOS image of DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synapsin and Rab8. Dashed white box denotes single-plane insets on right. Arrowheads denote Lifeact-GFP, Synapsin, and Rab8 puncta in the pioneer growth cone. (F and G) Super-resolution DeSOS images of a DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synaptotagmin (F) and SV2 (G). Dashed white box denotes single-plane insets on right. Arrowheads denote colocalized Lifeact-GFP and vesicle puncta. Tukey’s HSD used for (C). SEM is shown. Scale bars, 10 mm. See also Figure S1 and Video S1.

Journal: Current biology : CB

Article Title: Synaptic-like Vesicles Facilitate Pioneer Axon Invasion.

doi: 10.1016/j.cub.2019.06.078

Figure Lengend Snippet: Figure 1. Synaptic-like Vesicles Accumulate in Pioneer DRG Growth Cones at the DREZ (A) Confocal z projections of DRG pioneer axon navigation in a Tg(sox10:syn-gfp); Tg(sox10:mcherry) animal from a 24-h time-lapse starting at 48 hpf. Syn-GFP vesicles accumulate in the growth cone upon DREZ contact. White arrows denote Syn-GFP concentrate. Dashed orange boxes denote DREZ. (B) Tracing of growth cone Syn-GFP intensity throughout navigation. Blue box denotes DREZ entry. Dashed line denotes SEM (n = 4 DRG). (C) Growth cone Syn-GFP intensities before, during, and after DREZ localization (n = 4 DRG). (D) Quantification of actin clusters in DREZ-located DRG pioneer axons containing vesicle puncta (n = 16 growth cones; n = 52 actin clusters). (E) Super-resolution DeSOS image of DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synapsin and Rab8. Dashed white box denotes single-plane insets on right. Arrowheads denote Lifeact-GFP, Synapsin, and Rab8 puncta in the pioneer growth cone. (F and G) Super-resolution DeSOS images of a DRG pioneer axon at the DREZ in a Tg(sox10:lifeact-gfp) animal stained for Synaptotagmin (F) and SV2 (G). Dashed white box denotes single-plane insets on right. Arrowheads denote colocalized Lifeact-GFP and vesicle puncta. Tukey’s HSD used for (C). SEM is shown. Scale bars, 10 mm. See also Figure S1 and Video S1.

Article Snippet: Primary antibodies used in this study are Synapsin 1/2 (1:1000, rabbit, Synaptic Systems, catalog #: 106 102 [59], Rab8 (1:500, mouse, Novus Biologicals, catalog #: H00004218-M02), RFP to detect tag-BFP (1:100, rabbit, Thermo Fisher, catalog #: R10367), Znp-1 (Synaptotagmin 2, 1:500, mouse, DHSB), SV2A (1:500, mouse, DHSB), MMP14 (1:500, rabbit, Sigma, catalog #: AB6005) [34].

Techniques: Staining

Figure 5. MMP14a Localizes to Actin Clusters and Some Synaptic Vesicle Markers (A–C) Single-plane super-resolution, Imaris growth cone isolation images of DREZ-located growth cones in Tg(sox10:lifeact-gfp) animals stained for MMP14 and Synaptotagmin (A), SV2 (B), or Rab8 (C) at 56 hpf. Arrowheads denote MMP14 and/or vesicle puncta. (D) Quantification of actin clusters at the DREZ per growth cone that are MMP14+ and MMP14 (n = 41 growth cones). (E) Percent of actin clusters that colocalize with MMP14 and/or Synaptotagmin (n = 18 growth cones). (F) Confocal single-plane images of DREZ-located growth cones in Tg(sox10:syn-gfp) animals stained for MMP14. Arrowheads denote MMP14 puncta. (G) Percentage of MMP14 puncta that colocalize with vesicle markers. (H) Percentage of vesicle puncta that localize to MMP14 (n = 18 synaptotagmin stained; n = 8 SV2 stained; n = 15 Rab8-stained growth cones). (I–K) MMP14 intensity in Synaptotagmin- (I), SV2- (J), and Rab8 (K)-stained growth cones. Black bars denote actin-localized puncta. Gray bars denote puncta that do not localize to actin concentrates (n = 43 Synaptotagmin; n = 14 SV2; n = 5 Rab8 puncta). SEM is shown. Scale bars, 10 mm. See also Figure S3.

Journal: Current biology : CB

Article Title: Synaptic-like Vesicles Facilitate Pioneer Axon Invasion.

doi: 10.1016/j.cub.2019.06.078

Figure Lengend Snippet: Figure 5. MMP14a Localizes to Actin Clusters and Some Synaptic Vesicle Markers (A–C) Single-plane super-resolution, Imaris growth cone isolation images of DREZ-located growth cones in Tg(sox10:lifeact-gfp) animals stained for MMP14 and Synaptotagmin (A), SV2 (B), or Rab8 (C) at 56 hpf. Arrowheads denote MMP14 and/or vesicle puncta. (D) Quantification of actin clusters at the DREZ per growth cone that are MMP14+ and MMP14 (n = 41 growth cones). (E) Percent of actin clusters that colocalize with MMP14 and/or Synaptotagmin (n = 18 growth cones). (F) Confocal single-plane images of DREZ-located growth cones in Tg(sox10:syn-gfp) animals stained for MMP14. Arrowheads denote MMP14 puncta. (G) Percentage of MMP14 puncta that colocalize with vesicle markers. (H) Percentage of vesicle puncta that localize to MMP14 (n = 18 synaptotagmin stained; n = 8 SV2 stained; n = 15 Rab8-stained growth cones). (I–K) MMP14 intensity in Synaptotagmin- (I), SV2- (J), and Rab8 (K)-stained growth cones. Black bars denote actin-localized puncta. Gray bars denote puncta that do not localize to actin concentrates (n = 43 Synaptotagmin; n = 14 SV2; n = 5 Rab8 puncta). SEM is shown. Scale bars, 10 mm. See also Figure S3.

Article Snippet: Primary antibodies used in this study are Synapsin 1/2 (1:1000, rabbit, Synaptic Systems, catalog #: 106 102 [59], Rab8 (1:500, mouse, Novus Biologicals, catalog #: H00004218-M02), RFP to detect tag-BFP (1:100, rabbit, Thermo Fisher, catalog #: R10367), Znp-1 (Synaptotagmin 2, 1:500, mouse, DHSB), SV2A (1:500, mouse, DHSB), MMP14 (1:500, rabbit, Sigma, catalog #: AB6005) [34].

Techniques: Isolation, Staining